Isoforms Confer Characteristic Force Generation and Mechanosensation by Myosin II Filaments
نویسندگان
چکیده
منابع مشابه
Isoforms Confer Characteristic Force Generation and Mechanosensation by Myosin II Filaments.
Myosin II isoforms with varying mechanochemistry and filament size interact with filamentous actin (F-actin) arrays to generate contractile forces in muscle and nonmuscle cells. How myosin II force production is shaped by isoform-specific motor properties and environmental stiffness remains poorly understood. Here, we used computer simulations to analyze force production by an ensemble of myosi...
متن کاملForce generation by Myosin II Filaments in Compliant Networks
Myosin II isoforms with varying mechanochemistry and filament size interact with filamentous actin (F-actin) networks to generate contractile forces in muscle and non-muscle cells. How their properties control force production in environments with varying stiffness remains poorly understood. Here, we incorporated literature values for biophysical properties of myosin II isoforms into a cross-br...
متن کاملStochastic force generation by small ensembles of myosin II motors.
Forces in the actin cytoskeleton are generated by small groups of nonprocessive myosin II motors for which stochastic effects are highly relevant. Using a cross-bridge model with the assumptions of fast power-stroke kinetics and equal load sharing between equivalent states, we derive a one-step master equation for the activity of a finite-sized ensemble of mechanically coupled myosin II motors....
متن کاملUnderstanding the cooperative interaction between myosin II and actin cross-linkers mediated by actin filaments during mechanosensation.
Myosin II is a central mechanoenzyme in a wide range of cellular morphogenic processes. Its cellular localization is dependent not only on signal transduction pathways, but also on mechanical stress. We suggest that this stress-dependent distribution is the result of both the force-dependent binding to actin filaments and cooperative interactions between bound myosin heads. By assuming that the...
متن کاملForce generation by actin polymerization II: the elastic ratchet and tethered filaments.
The motion of many intracellular pathogens is driven by the polymerization of actin filaments. The propulsive force developed by the polymerization process is thought to arise from the thermal motions of the polymerizing filament tips. Recent experiments suggest that the nucleation of actin filaments involves a phase when the filaments are attached to the pathogen surface by a protein complex. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.03.030